{"id":2730,"date":"2026-05-04T04:50:54","date_gmt":"2026-05-04T04:50:54","guid":{"rendered":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/xenografting-of-breast-cancer-cells-2\/"},"modified":"2026-05-04T04:50:55","modified_gmt":"2026-05-04T04:50:55","slug":"xenografting-of-breast-cancer-cells-2","status":"publish","type":"post","link":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/xenografting-of-breast-cancer-cells-2\/","title":{"rendered":"Xenografting of Breast Cancer Cells using VitroGel System"},"content":{"rendered":"<figure class=\"project-feature\">\n<img decoding=\"async\" alt=\"\" src=\"http:\/\/sciencewerke.local\/wp-content\/uploads\/2026\/04\/VitroGel-Research.jpg\" style=\"width:100%;padding-bottom: 10px;\"\/><br \/>\n<\/figure>\n<p class=\"text-justify\">RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.<\/p>\n<p class=\"text-justify\">In this research highlight, a joint team of researchers from Korean and Japanese cancer institutes performed a series of in vitro and in vivo experiments to investigate the expression and mode of action of the ring-finger protein RFN208. VitroGel, a xeno-free injectable hydrogel system was used for xenografting of triple-negative breast cancer cells into mice to help cell retention and test tumor growth in response to the upregulation of a ubiquitin-related ligase protein. The results show that RNF208 expression is closely associated with Vimentin-mediated aggressive cancer progression of breast cancer cells.<\/p>\n<p class=\"text-justify\">Click <a href=\"https:\/\/www.thewellbio.com\/rnf208-suppress-metastasis-triple-negative-breast-cancer\/?utm_source=newsletter&amp;utm_medium=sendy&amp;utm_campaign=RNF208_highlight#main\" style=\"color: #178fcf;\" target=\"_blank\">here<\/a> for the full research highlights.<\/p>\n<p class=\"text-justify\"><a href=\"https:\/\/www.thewellbio.com\/research-highlights\/conversion-normal-cells-to-pro-tumorigenic-lung-cancer-cells\/#main\" style=\"color: #178fcf;\" target=\"_blank\">Read<\/a> how VitroGel helps with this research.<\/p>\n<p class=\"text-justify\">Do you know that xeno-free VitroGel hydrogels can be used as a Matrigel alternative for 3D cell culture research? Click <a href=\"https:\/\/www.thewellbio.com\/3d-cell-culture-hydrogel\/vitrogel-hydrogel\/#main\" style=\"color: #178fcf;\" target=\"_blank\">here<\/a> to find out more.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. In this research highlight, a joint team of researchers from Korean and Japanese cancer institutes performed a series of in vitro and in vivo experiments to investigate the expression and mode of action of the ring-finger protein RFN208. VitroGel, a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1850,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[166],"tags":[],"class_list":["post-2730","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-166"],"_links":{"self":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/2730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/comments?post=2730"}],"version-history":[{"count":1,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/2730\/revisions"}],"predecessor-version":[{"id":2795,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/2730\/revisions\/2795"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/media\/1850"}],"wp:attachment":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/media?parent=2730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/categories?post=2730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/tags?post=2730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}