{"id":1801,"date":"2026-04-30T13:17:22","date_gmt":"2026-04-30T13:17:22","guid":{"rendered":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/pathogenic-genomic-insights\/"},"modified":"2026-04-30T13:17:24","modified_gmt":"2026-04-30T13:17:24","slug":"pathogenic-genomic-insights","status":"publish","type":"post","link":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/pathogenic-genomic-insights\/","title":{"rendered":"Want to get to pathogenic genomic insights?"},"content":{"rendered":"<figure class=\"project-feature\"> <img decoding=\"async\" alt=\"Sciencewerke\" src=\"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-content\/uploads\/2026\/04\/WhatsApp%20Image%202024-03-14%20at%205.23.13%20PM.webp\" style=\"padding-bottom: 20px;width: 70%;\"\/> <\/figure>\n<p class=\"text-justify\">With Bionano optical genome mapping (OGM) you can finally detect previously unseen,<br \/>\npathogenic variants, in hematological malignancies.<\/p>\n<p class=\"text-justify\">In a single assay, the OGM Saphyr \u00ae \u00a0system can detect all classes of chromosomal<br \/>\naberrations in hematological malignancies, revealing critical structural variants (SVs) hidden<br \/>\nin the genome that have never been seen before. <\/p>\n<ul style=\"list-style-type: disc;\">\n<li>\n<p>Accurately identify all classes of SVs<\/p>\n<\/li>\n<li>\n<p>500 base pair resolution<\/p>\n<\/li>\n<li>\n<p>5% variant allele frequency<\/p>\n<\/li>\n<li>\n<p>10,000x more resolution than karyotyping, less subjective results<\/p>\n<\/li>\n<\/ul>\n<p class=\"\" style=\"font-size: 18px;\"> The genome-wide OGM platform uses unbiased, digital precision to reveal the pathogenic<br \/>\nstructural variants that can increase the number of resolved hematological malignancy<br \/>\nsamples, and better stratify risk profiles. No more having to sign off on sample reports as \u201cno<br \/>\ngenetic determinant identified\u201d because the technology wasn\u2019t there to reveal the pathogenic<br \/>\ncytogenetic variants.<\/p>\n<p class=\"\" style=\"font-size: 18px;\">The Saphyr \u00ae \u00a0system consolidates multiple technologies into one to create a single, simple,<br \/>\nOGM sample-to-answer workflow. Now there is a single method for studying all structural<br \/>\nand numerical variant classes. The Saphyr \u00ae \u00a0system is a streamlined workflow, easy to<br \/>\nimplement, with no need for cell culture or complex and subjective microscope analysis,<br \/>\nsystem.<\/p>\n<figure class=\"project-feature\"> <img decoding=\"async\" alt=\"Sciencewerke\" src=\"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-content\/uploads\/2026\/04\/WhatsApp%20Image%202024-03-14%20at%205.23.12%20PM.webp\" style=\"padding-bottom: 20px;width: 70%;\"\/> <\/figure>\n<p class=\"\" style=\"font-size: 18px;\">\n\t\t\t\t\tJoin the growing community of cytogeneticists, pathologists and hematopathologists who are<br \/>\nembracing OGM to maximize their number of relevant cases and uncover new ways forward<br \/>\nto seeing variants of biological significance.\n\t\t\t\t\t<\/p>\n<p><iframe loading=\"lazy\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\" frameborder=\"0\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/tLsTeMur64o?si=52sIKMfSN99pAopT\" title=\"YouTube video player\" width=\"560\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>With Bionano optical genome mapping (OGM) you can finally detect previously unseen, pathogenic variants, in hematological malignancies. In a single assay, the OGM Saphyr \u00ae \u00a0system can detect all classes of chromosomal aberrations in hematological malignancies, revealing critical structural variants (SVs) hidden in the genome that have never been seen before. Accurately identify all classes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164],"tags":[],"class_list":["post-1801","post","type-post","status-publish","format-standard","hentry","category-164"],"_links":{"self":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/1801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/comments?post=1801"}],"version-history":[{"count":2,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/1801\/revisions"}],"predecessor-version":[{"id":2656,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/posts\/1801\/revisions\/2656"}],"wp:attachment":[{"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/media?parent=1801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/categories?post=1801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pm11.corsivalab.xyz\/sciencewerke\/wp-json\/wp\/v2\/tags?post=1801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}