Metabolomics comprehensively characterizes small polar and lipid metabolites that are uniquely from bacterial processing or shared with the host and modified within the microenvironment of the microbiota. This facilitates the understanding of metabolites and their biological implications in host-microbiota interactions, including their involvement in a multitude of complex diseases, such as cardiovascular disease, metabolic syndromes, and obesity. Furthermore, their involvement in various aspects of these diseases can provide more insights on how to improve current precision medicine approaches, including personalized dietary interventions.
HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure small polar metabolites (including short chain fatty acids, modified indoles, polyamines, etc.), and dipeptides, in many types of samples, from sweat, tears to blood and fecal matter.
Quantitation
Over 100 polar metabolites, many of which can be altered by the microbiome, are quantifiable with single- or multi-point calibration.
High resolution
Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.
Examples of samples that can be analyzed at HMT
Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
biomarkers & diagnostic markers relating to disease severity, stress, inflammation
monitor disease progression &/or drug response
Urine, feces, cecal contents
pathogen-induced dysbiosis
detect inflammation-derived changes in metabolic profiles
Cultured cells
changes in energy metabolism in infected cells
assessment of novel therapeutics
Tissues from target organs
interactions between specific tissues & pathogens
monitor metabolic changes for enhanced evaluation of disease progression
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