Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, metabolomics profiling can help to identify specific metabolic changes in cancer cells and tissues, providing a deeper understanding of the role altered cellular metabolism plays in tumorigenesis, as well as in disease progression. Furthermore, targeting cancer metabolism pathways with metabolomics will be useful in determining critical biomarkers for early detection and therapeutic interventions.
HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure metabolites related to cellular energy metabolism, e.g., amino acids, short-chain fatty acids, polyamines, in most types of samples, including blood, tissues, and cultured cells.
Quantitation
Over 100 polar metabolites involved in cancer metabolism are quantifiable with single- or multi-point calibration.
High resolution
Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.
Examples of samples that can be analyzed at HMT
Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
biomarkers & diagnostic markers relating to disease severity, stress, inflammation
monitor disease progression &/or drug response
Urine, feces, cecal contents
pathogen-induced dysbiosis
detect inflammation-derived changes in metabolic profiles
Cultured cells
changes in energy metabolism in infected cells
assessment of novel therapeutics
Tissues from target organs
interactions between specific tissues & pathogens
monitor metabolic changes for enhanced evaluation of disease progression
For overview of analysis services, click on more info