Vysis CLL FISH Probe Kit is a test to detect deletion of the LSI TP53, LSI ATM, and LSI D13S319 probe targets and gain of the D12Z3 sequence probe target via fluorescence in situ hybridization (FISH) in peripheral blood specimens from patients with B-cell chronic lymphocytic leukemia (CLL) to aid in identifying those patients eligible for treatment with Venclexta® (venetoclax).
This kit contains five reagents sufficient to process 20 assays.
An assay is defined as one 22 mm x 22 mm Vysis LSI TP53 SpectrumOrange/ATM SpectrumGreen probe hybridization area and one 22 mm x 22 mm Vysis LSI D13S319 SpectrumOrange/13q34 SpectrumAqua/CEP 12 SpectrumGreen probe hybridization area.
Each kit includes:
Vysis LSI D13S319 SpectrumOrange/LSI 13q34 SpectrumAqua/CEP 12 SpectrumGreen Probes (1 vial, 200 µL/vial)
Vysis LSI TP53 SpectrumOrange/LSI ATM SpectrumGreen Probes (1 vial, 200 µL/vial)
DAPI II Counterstain (1 vial, 600 µL/vial)
NP-40 (2 vials, 200 µL/vial)
20X Standard Sodium Citrate (SSC) Salt (1 bottle, 66 g)